Archive for April, 2015

at last DNA is looking like it is going to have real breeding impact

Excited to see the publication of

Bartolomé N, Segarra S, Artieda M, Francino O, Sánchez E, et al. (2015) A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches. PLoS ONE 10(4): e0122558. doi:10.1371/journal.pone.0122558

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122558

in the author’s words:

“In conclusion, we have developed a logistic model with a good accuracy for CHD prediction in Labrador retrievers based on the combination of 7 SNPs, several of them located near genes involved in extracellular matrix processes or bone metabolism. Our results in Labrador retrievers add evidence to the thought that genomics is the basis towards early detection of CHD. Whether our predictive model is valid or not for other dog breeds needs to be explored.”

 

Another hip dysplasia study to watch for is Mapping of Genetic Risk Factors for Canine Hip Dysplasia – See more at: http://www.akcchf.org/research/funded-research/1828.html#sthash.vB1B8vGS.dpuf

 

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